A protein kinase bound to the projection portion of MAP 2 (microtubule-associated protein 2)
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چکیده
منابع مشابه
A protein kinase bound to the projection portion of MAP 2 (microtubule-associated protein 2)
In previous work we have demonstrated that the microtubule-associated protein 2 (MAP 2) molecule consists of two structural parts. One part of the molecule, referred to as the assembly-promoting domain, binds to the microtubule surface and is responsible for promoting microtubule assembly; the other represents a filamentous projection observed on the microtubule surface that may be involved in ...
متن کاملMAP 2 ( microtubule - associated protein 2 )
Four transcription variants have been characterized. MAP2 Isoform 5 (NM_001039538.1 --> NP_001034627.1): The difference in this isoform is characterized by the 5' UTR which results in the production of a longer protein when compared to isoform 2. MAP2 Isoform 1 (NM_002374.3 --> NP_002365.3): This isoform is thought to be the longest encoded and contains three alternative in-frame exons when com...
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The G protein-coupled receptor kinase 2 (GRK2) is a serine/threonine kinase that phosphorylates and desensitizes agonist-occupied G protein-coupled receptors (GPCRs). Here we demonstrate that GRK2 is a microtubule-associated protein and identify tubulin as a novel GRK2 substrate. GRK2 is associated with microtubules purified from bovine brain, forms a complex with tubulin in cell extracts, and ...
متن کاملGenomic structure of human microtubule-associated protein 2 (MAP-2) and characterization of additional MAP-2 isoforms.
We have determined that the gene for human microtubule-associated protein 2 (MAP-2) spans 19 exons, including 6 exons identified in this study, 1-4, 8, and 13; all six of these exons are transcribed. The alternative splicing of coding exons generates a greater diversity of MAP-2 transcripts and isoforms. The first three exons encode alternate 5' untranslated regions that can be spliced to addit...
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Objective(s):EMAP-like Protein 5 (EML5) is a new echinoderm microtubule-associated protein that is expressed in the central nervous system. The aim of this study was to investigate the expression profile of EML5 in the anterior temporal neocortex of patients presenting with intractable epilepsy (IE). Materials and Methods:Western blot assays were performed to determine EML5 expression in 36 su...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 1981
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.90.3.568